IndraLab

Statements

reach
"CAPE is yet able to suppress IRF-3 activation, following inflammation or innate immune response [XREF_BIBR] but this activity may follow cell regulation of virus infection, which allows that the E3 ubiquitin ligase RBCC protein interacting with PKC1 (RBCK1) binds to IRF-3 and targets it for ubiquitination and subsequent degradation through a proteasome dependent pathway, to dampen the overexpression of RBCK1 by virus and reduce side effects as autoimmune disorders due to the excessive activity of IFNs [XREF_BIBR]."
27104045
reach
"CAPE suppressed production of inflammatory mediators and activation of NFkappaB and interferon-regulatory factor 3 (IRF3) in macrophages stimulated with LPS."
23231684