IndraLab

Statements

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"Functionally, the overexpression of OTUB2 could promote malignant proliferation and metastasis of HCC cells, while knockdown of OTUB2 exerted the opposite results."
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"Compared to the early passage parental MDA-MB-231 cells, the highly bone-metastatic (BM) derivatives also showed elevated expression of OTUB2 ( Figure 1 C), suggesting OTUB2 could support metastasis."
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"These results support a notion that both DUB activity and SUMO modification of OTUB2 are required to promote lung metastasis in a syngenic mouse tumor model.To further substantiate the function of OTU[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"As for breast cancer, a recent study reported that OTUB2 deubiquitinated and activated YAP/TAZ to promote cancer stemness and metastasis (Zhang et al., 2019), which confirms the reliability of our results."
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"OTUB2 was identified to enhance breast cancer metastasis."
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"OTUB2 was reported to enhance metastasis through Hippo-independent activation of YAP/TAZ signaling, which could stabilize YAP/TAZ by deubiquitination [37]."
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"Inhibition of OTUB2 promotes apoptosis and attenuates proliferation and metastasis of CC cells by downregulating the AKT/mTOR signalling pathway (Ref."
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"Zhang et al. [12] demonstrated that OTUB2 promoted tumor metastasis by independently activating YAP and TAZ."
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"In addition, OTUB2 promotes breast cancer metastasis by stabilizing Yes-associated protein/WW domain-containing TFs ( Zhang et al., 2019 )."
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"We subsequently examined the role of YAP/TAZ in OTUB2-enhanced cancer stemness and metastasis."
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"These results indicate that OTUB2-regulated expression of ZEB1 enhances EMT to promote invasion and metastasis in iCCA cells ( Fig. 4 E and F)."
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"Moreover, overexpression of OTUB2 significantly promoted the migration and metastasis of tumor cells."
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"OTUB2 was reported to enhance metastasis through Hippo-independent activation of YAP / TAZ signaling , which could stabilize YAP / TAZ by deubiquitination [ 37 ] ."
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"These indicate that OTUB2 promotes the metastasis of iCCA cells through ZEB1-regulated EMT.CTNNB1 signaling is involved in many physiological and pathological processes, as shown in previous works [ 2[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"OTUB2-WT expression increased spontaneous lung metastasis without affecting primary tumor growth, whereas expression of OTUB2-CS or OTUB2-KR had no significant effects ( Figure 5 E–5H)."
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"However, in a study of breast cancer, OTUB2 promoted metastasis through hippocampal-independent activation of YAP and TAZ [26]."
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