IndraLab

Statements

COPS6 activates Aldh1a1 mRNA. 5 / 5
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"Importantly , CSN6 caused an increase in the Aldh1a1 mRNA level and that overexpression of TRIM21 led to a decrease in the Aldh1a1 mRNA level , even in the presence of CSN6 ( Fig. 2l ) ."
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"In addition , quantitative RT-PCR analysis indicated that CSN6 knockdown caused a decrease in the Aldh1a1 mRNA level but failed to do so when TRIM21 was also knocked down ( Fig. 2m ) ."
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"We further showed that CSN6 expression caused a significant increase in the Aldh1a1 mRNA level in control cells but not in TRIM21 KO cells ( Fig. 2n ) ."
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"Accordingly , CSN6 knockdown led to a decrease in the level of Aldh1a1 mRNA ( Fig. 1d ) , while ectopic expression of CSN6 in both the HCT116 and DLD-1 cell lines resulted in increased Aldh1a1 mRNA levels ( Fig. 1d ) ."
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"CSN6 regulates ALDH1A1 expression through TRIM21 To investigate how knockdown of CSN6 can lead to reduced expression of Aldh1a1 mRNA , we determined whether CSN6-associated proteins might have a role ."
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