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Estrogen activates USP1. 2 / 2
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"This antagonistic effect of progesterone on estrogen induced USP-1 biosynthesis was also evident by the decreased staining intensity of USP-1 in uterine epithelial cells, as revealed by the immunohistochemical method."

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"In the present communication, the effects of progesterone and antiprogesterone (RU 38486) on estrogen stimulated USP-1 biosynthesis were investigated."