IndraLab

Statements

Digoxin activates KCNH2. 4 / 4
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"Digitoxin, ouabain, and digoxin appear to inhibit IKr by reducing the density of HERG dependent potassium channels in the cell membrane."
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"CHIP ablation partially suppressed ouabain- or digoxin induced hERG disposal from the PM (XREF_FIG)."
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"Digitoxin, ouabain, and digoxin seem to inhibit IKr by decreasing the density of hERG dependent potassium channels on the cell membrane."
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"Ouabain or digoxin treatment (300 nM for 1.5 h) accelerated hERG internalization by greater than twofold in HeLa and H9C2 i cells, as determined by anti-HA Ab uptake assay (XREF_FIG)."
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