IndraLab

Statements

USP1 inhibits FANCI. 2 / 3
1 | 1
reach
"However, in FA pathway, disruption of USP1 gene causes accumulation of the monoubiquitinated forms of FANCD2 and FANCI but increases ICL hypersensitivity and genomic instability [XREF_BIBR, XREF_BIBR]."
27398234
signor
"Phosphorylation of FANCI may also turn the ubiquitinated ID complex into a poor substrate for deubiquitination by the USP1–UAF1 complex, resulting in increased levels of monoubiquitinated FANCD2."
18985065