IndraLab

Statements

USP22 inhibits AKT. 5 / 6
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"Smad silencing can block the downregulation of Akt induced by USP22 knockdown and reverse 5-FU resistance [ 77 ]."
33989708
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"Furthermore, our results showed that USP22 deletion also caused down-regulation of Akt and GSK3beta activity, which can also contribute to the reduction of cyclin D2."
21928107
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"Silencing Smad4 blocked USP22 knockdown induced Akt inhibition in Bel/Fu cells."
28445968
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"USP22 prevents ubiquitination-mediated EGFR degradation, thereby inducing persistent activation of EGFR-mediated oncogenic signaling pathways, such as STAT3, AKT/mTOR, and MEK/ERK pathways."
35935969
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"Downregulation of USP22 Inhibited the Activation of PI3K and Akt Signaling Pathway."
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