IndraLab

Statements

OTUD5 decreases the amount of GPX4. 2 / 2
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"As shown in ubiquitination assays, OTUD5 significantly downregulated the ubiquitination level of GPX4 in the presence of WT ubiquitin and K48 ubiquitin."
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"Importantly, OTUD5 did not decrease the ubiquitination level of GPX4 in K48R‐transfected cells, but the levels decreased in cells transfected with the ubiquitin mutant K63R, indicating that OTUD5 cleaves the K48‐linked ubiquitination of GPX4 rather than K63‐linked chains (Figure 4G)."
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