IndraLab

Statements

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"These findings are consistent with the idea that USP22 promotes the non T cell inflamed TME and suppresses antitumor immunity in PDA."
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"100 Another DUB, USP22, also stabilizes PD-L1 in tumor cells via deubiquitination and suppresses antitumor immunity in mouse tumor models."
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"Collectively, these experiments suggest that USP22 expression in PDA tumors cells suppresses antitumor immunity and confers resistance to immunotherapy."
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"Tumor cell-intrinsic USP22 suppresses antitumor immunity in pancreatic cancer."
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"What more excited is that USP22 can inhibit the antitumor immunity, efficacy of PDL1 targeted immunotherapy by inhibiting the deubiquitinase of PDL1 (CD274) [XREF_BIBR], which is consistent with our results."
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