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Sitagliptin inhibits NLRP3. 6 / 6
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"Therefore, Sitagliptin was able to attenuate radiation-induced activation of NLRP3 inflammasome in intestinal epithelial cells.To further investigate the potential clinical application value of Sitagliptin for radiotherapy, we further examined the effect of Sitagliptin on tumor growth in vivo."
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"18 Interestingly, some studies found that sitagliptin also inhibited the NLRP3 inflammasome 23 via an identical mechanism to that used by irisin to inhibit inflammatory cytokines."
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"Recently , it has been demonstrated that sitagliptin and linagliptin can suppress the activity of NLRP3 / inflammasome in an experimental model of renal injury [ 141 ] ."
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"Sitagliptin and linagliptin also suppressed the activity of NLRP3 and inflammasome in an experimental model of nephropathy."
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"Recently, it has been demonstrated that sitagliptin and linagliptin can suppress the activity of NLRP3/inflammasome in an experimental model of renal injury [141]."
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"However, it remains to be determined whether Sitagliptin inhibited NLRP3 inflammasome relying on the activation of NRF2.In addition, we also investigated the effects of Sitagliptin on gut microbiota after radiation."
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