IndraLab

Statements

USP15 inhibits IRF3. 5 / 5
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reach
"As shown in XREF_FIG e and XREF_FIG f, knockdown of USP15 increased the activation of NF-kappaB (5.9 vs 12.9, p = 1.92E-04) and IRF3 (15.6 vs 26.5, p = 1.04E-03) through reporter assays."
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"In addition, USP15 dose-dependently inhibited RIG-I-N-triggered IFN-beta-Luc, ISRE-Luc, NF-kappaB-Luc, and IRF3-Luc reporter activities."
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"As shown in Fig. 1e and 1f, knockdown of USP15 increased the activation of NF-κB (5.9 vs 12.9, p = 1.92E-04) and IRF3 (15.6 vs 26.5, p = 1.04E-03) through reporter assays."
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"In addition, USP15 dose-dependently inhibited RIG-I-N-triggered IFN-β–Luc, ISRE–Luc, NF-κB–Luc, and IRF3–Luc reporter activities (Supplementary Fig. S3)."
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"(c–e) USP15 inhibited SEV-induced activation of ISRE and the NF-κB and IRF3 promoters."
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