IndraLab

Statements


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"Abnormalities in the function of BAP1 can induce inappropriate Ca influx into mitochondria, which may affect the regulation of apoptosis and lead to carcinogenesis ."

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"Loss of BAP1 or its DUB activity down-regulates IP 3 R3 and calcium flux, thereby preventing apoptosis of cells with DNA damages."

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"(ii) The tumor suppressor BRCA1 associated protein 1 (BAP1), a deubiquitylating enzyme, promotes ER-mitochondrial Ca 2+ transfer by stabilizing the IP 3 R3 114."

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"In a paper in press in Nature, 19 we report that BAP1 modulates ER-to-mitochondria calcium (Ca 2+) release."

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"In a paper in press in Nature, 19 we report that BAP1 modulates ER-to-mitochondria calcium (Ca 2+) release."