IndraLab

Statements

OTUD3 deubiquitinates HSPA5. 3 / 3
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"Mechanistic studies indicated that OTUD3 promoted lung tumorigenesis by deubiquitylating and stabilizing GRP78 [26]."
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"OTUD3 plays an oncogenic role in lung cancer cells and promotes the development of lung cancer by directly interacting with GRP78, where OTUD3 deubiquitylates GRP78 and maintains GRP78 stability in vitro and in vivo."
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"The results showed that overexpression of OTUD3 significantly reduced the level of GRP78 ubiquitination, and the catalytically inactive mutant OTUD3 did not reduce the level of GRP78 ubiquitination."
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