IndraLab

Statements

UCHL3 activates HYCC1. 9 / 9
| 9
reach
"The observation of the growth volume and weight of tumors in nude mice indicates that UCHL3 significantly promoted the tumor growth of HCC cells (Fig. 1I-J)."
38965582
reach
"Knockdown of Vimentin inhibited HCC cell migration and suppressed UCHL3-induced HCC cell migration, as illustrated by wound healing and Transwell assays ( Figures 6A–C )."
36969045
reach
"Firstly, siRNA was used to knockdown the protein expression of EEF1A1 in UCHL3 overexpressing HCC cells, and the knockdown level was detected by western blot (Fig. 5A)."
38965582
reach
"Transwell assay suggested that knockdown of EEF1A1 significantly attenuated the HCC cells migration enhancement induced by UCHL3 overexpression (Fig. 5B)."
38965582
reach
"In conclusion, the findings suggest that UCHL3 promotes HCC cell migration through stabilizing Vimentin."
36969045
reach
"Together, the abovementioned results show that the DUB activity of UCHL3 stabilizes the expression of Vimentin and promotes the migration of HCC."
36969045
reach
"UCHL3 promoted HCC cell migration and stem-like properties.Cell migration and stem-like properties contribute to the aggressiveness of tumors and poor patient prognosis (43)."
36969045
reach
"Functional rescue experiments indicated the dependence of UCHL3-mediated HCC cell migration on Vimentin regulation.Previous reports have indicated the deubiquitinating and protein-stabilizing effect of UCHL3 in several human cancer types (19, 20, 22) and demonstrated its contribution to carcinogenesis (14)."
36969045
reach
"The DUB activity of UCHL3 stabilized Vimentin and promoted HCC malignant progression."
36969045