IndraLab

Statements

USP11 decreases the amount of USP11. 4 / 6
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"Thereby, inhibiting USP11 function, via either blocking USP11 activity or lowering USP11 protein level, may serve as an effective therapeutic strategy against AD."
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"To investigate whether USP11 modulates LPS induced signaling, USP11 expression was down-regulated by usp11 shRNA transfection."
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"Similarly, USP11 KD decreased levels of the c-Myc target genes MCM3, CDC6, CCNE2, MKI67, and CDK4 in Rv1 (SI Appendix, Fig. S2L), VCaP (SI Appendix, Fig. S2M), C4-2 (SI Appendix, Fig. S2N), and DU145 (SI Appendix, Fig. S2O) cells.To evaluate the potential relevance of these in vitro findings to PCa tissues, we analyzed and correlated USP11 transcript levels with those of AR or c-Myc in human PCa datasets."
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"To investigate whether down-regulation of USP11 exhibits protective effects against LPS induced lung injury, USP11 levels in the mouse lungs were down-regulated by usp11 shRNA in a lentiviral vector delivery system (XREF_FIG d)."
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