IndraLab

Statements

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"OTUDin3 inhibits NSCLC cell growth, migration and invasion, and induces apoptosis by targeting OTUD3."
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"The results showed that the OTUD3-transfected cells were significantly more sensitive to cisplatin-induced apoptosis than the negative control cells (p < 0.01); however, the sensitivity of the transfected OTUD3 cells was significantly decreased (p < 0.01) (Fig. 7a)."
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"OTUDin3 induces NSCLC cell apoptosis."
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"The results showed that OTUDin3 induced apoptosis in H1299 cells in a concentration-dependent manner (Fig. 2E, F)."
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"Consistently, OTUDin3 increased the levels of apoptosis-associated proteins, Cleaved poly (ADP-ribose) polymerase (PARP) and Cleaved Caspase-3, in a concentration-dependent manner (Fig. 2G)."
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"Together, the results indicated that OTUDin3 induced NSCLC cell apoptosis."
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"Furthermore, OTUD3 silence promoted proliferation and motility and decreased apoptosis for HCT116 cells and restored partly miR-32-mediated cell proliferation, migration, and antiapoptosis for colon cancer."
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"Pu et al. reported that OTUD3 induced growth inhibition and apoptosis in invasive breast cancer cells through the direct deubiquitination and stabilization of p53 [37]."
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"MiR-32 also inhibits the expression of OTUD3 and promotes cell proliferation and motility and inhibits apoptosis in colon cancer cells (Jin et al., 2019)."
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"Taken together, these results demonstrated that OTUDin3 inhibited lung cancer cell growth, migration and invasion, and induced apoptosis by targeting OTUD3."
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