IndraLab

Statements

TNFAIP3 activates TNF. 9 / 9
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"A20/TNFAIP3 -deficient PECs produced TNF-α after nickel particle stimulation at both the mRNA and protein levels ( Fig. 4 D, 4E)."
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"The negative expression of TNFAIP3 inhibits TNF, and the unspecified expression of TNFAIP3 affects the catalysis of TNF."
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"It has not been determined whether TNFAIP3 -/- mucosal immune cells cause decreased IEC barrier function, but TNFAIP3 -/- immune cells produce higher amounts of TNF XREF_BIBR."
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"Consistent with these transcriptomic findings, qPCR analysis showed that TNFAIP3 mRNA levels were significantly elevated in both TNF-treated and ZIKV-infected cells compared to mock-treated cells (Fig. 5B)."
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"In addition to IFN pathway genes, the higher anti-viral activity of hub genes related to TNF signaling and NAD metabolisms such as TNFAIP3, PARP9, and DTX3L would be able to characterize patients with a high viral load, indicating a clear association of their expression to the presence of the virus and the phase of the disease."
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"TNFAIP3, a negative regulator of inflammation that inhibits NF-kB (nuclear factor kappa-B) and TNF (tumor necrosis factor)-mediated pathways, has been linked to several immune mediated diseases like T1D, systemic lupus erythematosus, and rheumatoid arthritis [XREF_BIBR, XREF_BIBR]."
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"This inhibition led to downregulation of TNFalpha induced NFkappaB target gene expression of IL6, ICAM1, and TNFAIP3, which had reduced basal and/or TNFalpha induced expression upon COUP-TFII overexpression."
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"As downstream genes of TNF, TNFAIP3 and TNFAIP6 may be overexpressed to activate the TNF-α signalling pathway."
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"TNFAIP3 protein as a zinc finger protein and ubiquitin shearing enzyme can suppress activated NF-kappaB signal pathway and induce apoptosis of TNF by activating ubiquitin ligase and ubiquitinase."
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