IndraLab

Statements

USP18 inhibits process. 4 / 4
| 2 2
eidos
"ISG15 is an IFN-induced protein that extracellularly stimulates the production of type II IFN , and intracellularly it binds lysine residues of proteins ( ISGylation ) ; this process can be reversed by USP18 ."
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sparser
"By comparing the behavior of IFNα2 mutants with different affinities for the two receptor subunits, the researchers concluded that IFNs do, in fact, recruit IFNAR1 into a ternary complex with IFNAR2, and that this process is inhibited by USP18. “Cells expressing USP18 lose the ability to bind IFNα2 because receptor dimerization isn’t as efficient,” Piehler says."
| PMC
sparser
"As in the ligand-binding assays, dimerization efficiency depended on the ligand’s affinity for IFNAR1, and the process was inhibited by USP18."
| PMC
eidos
"This process allows ISG15 to bind covalently to a range of target proteins , both viral and cellular [ 58 ] , by a process that is reversible due to the action of the ubiquitin-specific protease 18 ( USP18 ) , an event regulated by type I IFN [ 59 ] ."
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