IndraLab

Statements

OTUD6B activates KIFC1. 4 / 4
| 4
reach
"We next asked whether this OTUD6B depletion phenotype was dependent on its effects on KIFC1 levels, and therefore could be rescued by overexpressing KIFC1."
39789388
reach
"We confirmed that OTUD6B depletion reduced KIFC1 in the population of uninduced cells, but that this was overcome by acute induction of KIFC1 with doxycycline (Fig. 3H,I)."
39789388
reach
"This observation is consistent with OTUD6B promoting KIFC1 centrosome clustering activity early in mitosis to form a pseudo-bipolar spindle, along with an ongoing requirement to maintain KIFC1 levels and prevent de-clustering during anaphase."
39789388
reach
"This is consistent with a model where OTUD6B modulates KIFC1 accumulation in early mitosis, when supernumerary centrosome clustering is initially required for spindle formation."
39789388