IndraLab

Statements

USP22 increases the amount of MYC. 5 / 5
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"Levels of MYC, a critical transcription factor driver in many cancers, are enhanced by USP22 (REF."
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"For example, overexpression of USP22 upregulates the level of oncogenic c-MYC in breast cancer by promoting the deubiquitination of c-MYC, which is closely related with the progression of breast cance[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These data suggest that USP22 promotes GC progression.USP22 and c-Myc are co-expressed in GC tissues [7]."
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"It was found that USP22 positively regulates MYC protein levels and that USP22 promotes cancer progression by targeting k48-linked polyubiquitin chains to deubiquitinate MYC (137)."
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"The loss of USP22 can reduce the transcription of Myc and p53 by removing Ub from H2B.27 USP3 and USP21 also have functions in chromatin modification, leading to aberrant gene transcription.28 Loss of USP3 results in defects of the cell cycle, while USP21 can promote regenerative functions in hepatocytes."
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