IndraLab

Statements

CDK1 phosphorylates USP22. 15 / 27
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"Phosphorylation of USP22 by CDK1 enhances its activity in deubiquitinating CCNB1."
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"CDK1 phosphorylates USP22 to optimize its activity in CCNB1 stabilization during the G2/M phase."
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"From our proteomic analysis, we noticed that CCNB1 appears to form a complex with both USP22 and CDK1; this prompted us to ask whether CDK1 phosphorylates USP22."
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"We then analyzed whether USP22 is phosphorylated by CDK1."
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"In an in vitro kinase assay, co-incubation of the purified GST-USP22 fusion proteins and the constitutive forms of CDK1 (CDK1/AF) immunoprecipitated from transiently transfected HCT116 cells confirmed USP22 phosphorylation by CDK1 ( xref )."
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"Phosphorylation of USP22 by CDK1 enhances its activity in deubiquitinating CCNB1."
27030811
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"CDK1 phosphorylates USP22 to optimize its activity in CCNB1 stabilization during the G2/M phase."
27030811
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"From our proteomic analysis, we noticed that CCNB1 appears to form a complex with both USP22 and CDK1; this prompted us to ask whether CDK1 phosphorylates USP22."
27030811
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"We then analyzed whether USP22 is phosphorylated by CDK1."
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"In addition, expression of the constitutively active form of CDK1 (CDK1/AF) [XREF_BIBR, XREF_BIBR] further enhanced USP22 phosphorylation in HCT116 cells (XREF_FIG)."
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"CDK1 phosphorylates USP22 to enhance its activity in CCNB1 stabilization during G2/M phase."
27030811
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"CDK1 phosphorylates USP22 to enhance its activity in CCNB1 stabilization during G2/M phase."
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"Third, USP22 is phosphorylated by CDK1 during the G2/M phase of the cell cycle and this phosphorylation optimizes the enzyme activity of USP22 to deubiquitinate CCNB1."
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"Interestingly, USP22 activity is regulated by CDK1, which catalyzes USP22 phosphorylation to elevate USP22 ability in CCNB1 deubiquitination and stabilization."
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"Interestingly, USP22 is also phosphorylated by CDK1, and this phosphorylation enhances its activity in deubiquitinating cyclin B1."
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