IndraLab

Statements

CDK1 phosphorylates USP22. 26 / 27
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rlimsp
"CDK1 phosphorylates USP22 to enhance its activity in CCNB1 stabilization during G2/M phase."
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signor
"On the other hand, CDK1 enhances USP22 activity to stabilize CCNB1 during the G2/M phase.|Phosphorylation of USP22 by CDK1 enhances its activity in deubiquitinating CCNB1."
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rlimsp
"Cyclin-dependent kinase 1 (CDK1) phosphorylates ubiquitin-specific protease 22 (USP22) to promote its deubiquitinase activity."
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sparser
"Phosphorylation of USP22 by CDK1 enhances its activity in deubiquitinating CCNB1."
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rlimsp
"Third, USP22 is phosphorylated by CDK1 during the G2/M phase of the cell cycle and this phosphorylation optimizes the enzyme activity of USP22 to deubiquitinate CCNB1."
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sparser
"CDK1 phosphorylates USP22 to optimize its activity in CCNB1 stabilization during the G2/M phase."
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sparser
"From our proteomic analysis, we noticed that CCNB1 appears to form a complex with both USP22 and CDK1; this prompted us to ask whether CDK1 phosphorylates USP22."
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sparser
"We then analyzed whether USP22 is phosphorylated by CDK1."
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sparser
"In an in vitro kinase assay, co-incubation of the purified GST-USP22 fusion proteins and the constitutive forms of CDK1 (CDK1/AF) immunoprecipitated from transiently transfected HCT116 cells confirmed USP22 phosphorylation by CDK1 ( xref )."
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reach
"Phosphorylation of USP22 by CDK1 enhances its activity in deubiquitinating CCNB1."
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reach
"CDK1 phosphorylates USP22 to optimize its activity in CCNB1 stabilization during the G2/M phase."
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reach
"From our proteomic analysis, we noticed that CCNB1 appears to form a complex with both USP22 and CDK1; this prompted us to ask whether CDK1 phosphorylates USP22."
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reach
"We then analyzed whether USP22 is phosphorylated by CDK1."
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reach
"In addition, expression of the constitutively active form of CDK1 (CDK1/AF) [XREF_BIBR, XREF_BIBR] further enhanced USP22 phosphorylation in HCT116 cells (XREF_FIG)."
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reach
"CDK1 phosphorylates USP22 to enhance its activity in CCNB1 stabilization during G2/M phase."
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sparser
"CDK1 phosphorylates USP22 to enhance its activity in CCNB1 stabilization during G2/M phase."
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reach
"Third, USP22 is phosphorylated by CDK1 during the G2/M phase of the cell cycle and this phosphorylation optimizes the enzyme activity of USP22 to deubiquitinate CCNB1."
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reach
"Interestingly, USP22 activity is regulated by CDK1, which catalyzes USP22 phosphorylation to elevate USP22 ability in CCNB1 deubiquitination and stabilization."
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rlimsp
"From our proteomic analysis, we noticed that CCNB1 appears to form a complex with both USP22 and CDK1; this prompted us to ask whether CDK1 phosphorylates USP22."
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rlimsp
"In an in vitro kinase assay, co-incubation of the purified GST-USP22 fusion proteins and the constitutive forms of CDK1 (CDK1/AF) immunoprecipitated from transiently transfected HCT116 cells confirmed USP22 phosphorylation by CDK1 (Supplementary Figure S4d)."
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sparser
"Interestingly, USP22 is also phosphorylated by CDK1, and this phosphorylation enhances its activity in deubiquitinating cyclin B1."
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rlimsp
"These findings show that CDK1 is a kinase that catalyzes USP22 phosphorylation in a cell cycle-specific manner."
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rlimsp
"We then analyzed whether USP22 is phosphorylated by CDK1."
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rlimsp
"These results indicate that T147 and S237 are the potential CDK1 phosphorylation sites and imply that these residues have important functions in CDK1-mediated USP22 phosphorylation."
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rlimsp
"Phosphorylation of USP22 by CDK1 enhances its activity in deubiquitinating CCNB1."
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rlimsp
"CDK1 phosphorylates USP22 to optimize its activity in CCNB1 stabilization during the G2/M phase."
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