IndraLab

Statements

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"Furthermore, BAP1 knockdown inhibits tumorigenicity and lung metastasis, which can be rescued partially by ectopic expression of KLF5."
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"Finally, we wondered whether BAP1 and KLF5 promoted metastasis in vivo."
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"In conclusion, BAP1 is a KLF5 DUB and BAP1 promotes basal breast cell proliferation, migration, tumour growth and metastasis partially through stabilizing KLF5 (XREF_SUPPLEMENTARY)."
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"BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5."
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"BAP1 and KLF5 promote breast cancer migration, invasion and metastasis may not through p27; however, KLF5 is a transcription factor regulating numerous downstream target genes, such as FGF-BP and mPGES1."
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"Nevertheless, our results suggest that BAP1 promotes breast tumour growth and metastasis partially through stabilizing KLF5."
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"BAP1 and KLF5 promote breast cancer lung metastasis."
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"Therefore, these findings clearly indicate that BAP1 promotes breast cancer lung metastasis partially through stabilizing KLF5."
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"Furthermore, BAP1 loss abrogates tumor growth and lung metastasis in murine syngeneic tumor models."
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"Germline or somatic mutations and deletions of BAP1 have been identified in various tumor types, and downregulation or inactivation of BAP1 could accelerate tumor onset, invasion, recurrence, and metastases ."
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"BAP1 deletion abrogates growth and metastasis of murine cutaneous melanoma."
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"How BAP1 and KLF5 promote metastasis requires further investigation."
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"Nevertheless, the key node of BAP1 pathway in driving or mediating UM metastasis remains unexplored.LaFave LM et al. reported that knockout of BAP1 results in elevated transcription of EZH2 gene in acute myeloid leukemia mouse bone marrow cells and human mesothelioma cells [48]."
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"In this study, we discovered a novel positive regulatory mechanism for KLF5 and the functional mechanism by which BAP1 promotes breast cancer growth and metastasis."
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"Similarly, Qin et al. showed that knockdown of BAP1 in several breast cancer cell lines inhibited cell proliferation, tumorigenicity and metastasis."
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"Importantly, BAP1 stable knockdown suppressed tumour growth in HCC1806 cells and inhibited lung metastasis in 4T1 cells."
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"We killed all of the mice on day 32 and found that knockdown of BAP1 or KLF5 significantly decreased lung metastasis according to ex vivo bioluminescence imaging (XREF_FIG)."
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