IndraLab

Statements

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"Furthermore, BAP1 loss abrogates tumor growth and lung metastasis in murine syngeneic tumor models."
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"In conclusion, BAP1 is a KLF5 DUB and BAP1 promotes basal breast cell proliferation, migration, tumour growth and metastasis partially through stabilizing KLF5 (XREF_SUPPLEMENTARY)."
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"In this study, we discovered a novel positive regulatory mechanism for KLF5 and the functional mechanism by which BAP1 promotes breast cancer growth and metastasis."
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"Germline or somatic mutations and deletions of BAP1 have been identified in various tumor types, and downregulation or inactivation of BAP1 could accelerate tumor onset, invasion, recurrence, and metastases ."
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"Similarly, Qin et al. showed that knockdown of BAP1 in several breast cancer cell lines inhibited cell proliferation, tumorigenicity and metastasis."
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"Germline or somatic mutations and copy number alterations have been identified in several cancers and inactivation of BAP1 accelerates invasion, recurrence and metastases."
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"Nevertheless, our results suggest that BAP1 promotes breast tumour growth and metastasis partially through stabilizing KLF5."
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"BAP1 deletion abrogates growth and metastasis of murine cutaneous melanoma."
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"BAP1 and KLF5 promote breast cancer migration, invasion and metastasis may not through p27; however, KLF5 is a transcription factor regulating numerous downstream target genes, such as FGF-BP and mPGES1."
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"BAP1 depletion can inhibit the growth and metastasis of hepatocellular carcinoma cells [40]."
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"BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5."
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"Furthermore, BAP1 knockdown inhibits tumorigenicity and lung metastasis, which can be rescued partially by ectopic expression of KLF5."
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"BAP1 and BCL9L, as oncogenes, promote the growth, invasion and lung metastasis of breast cancer by interacting with β-catenin and Pygopus (39-41)."
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"In the bone, skin, and liver, UM metastasis was found to be caused by aberrant methylation of BAP1 and SF3B1."
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"Recent work has shown that BAP1 biallelic inactivation could promote metastasis development by enhancing immune evasion of the tumor through inhibition of the immune response [15], consistent with the limited response of UM to immunotherapy [9]."
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"One such example is the BAP 1 tumor suppressor gene, which, when mutated, elevates the risk of metastasis in UVM."
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"However, BAP1 was shown to promote breast cancer cell proliferation and migration, and lung cancer growth and metastasis [11] ."
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"Therefore, these findings clearly indicate that BAP1 promotes breast cancer lung metastasis partially through stabilizing KLF5."
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"Additionally, a mutational inactivation of the BAP 1 tumour-suppressor gene increases the risk of metastasis in uveal melanoma [22]."
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"BAP1 and KLF5 promote breast cancer lung metastasis."
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"For instance, loss of chromosome 3 and mutations in the BRCA1 associated protein 1 (BAP1) and splicing factor 3b subunit 1 genes frequently increase the risk of metastasis, and BAP1 is a tumor suppressor gene (8)."
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"Finally, we wondered whether BAP1 and KLF5 promoted metastasis in vivo."
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"We killed all of the mice on day 32 and found that knockdown of BAP1 or KLF5 significantly decreased lung metastasis according to ex vivo bioluminescence imaging (XREF_FIG)."
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"Nevertheless, the key node of BAP1 pathway in driving or mediating UM metastasis remains unexplored.LaFave LM et al. reported that knockout of BAP1 results in elevated transcription of EZH2 gene in acute myeloid leukemia mouse bone marrow cells and human mesothelioma cells [48]."
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"Importantly, BAP1 stable knockdown suppressed tumour growth in HCC1806 cells and inhibited lung metastasis in 4T1 cells."
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"How BAP1 and KLF5 promote metastasis requires further investigation."
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"The deubiquitinase (DUB) BRCA1-associated protein 1 (BAP1) stabilizes KLF5 and promotes BLBC growth and metastasis."
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