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TP53 bound to PIN1 activates TP53. 2 / 2

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"Another p53 binding protein is Pin1, which upon DNA damage induced phosphorylation of p53, binds to p53 and mediates a conformational change of p53 resulting in enhanced p53 transcriptional activity XREF_BIBR."

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"PIN1 interacts with p53 to enhance protein stability and transactivation activity of p53 to promote cellular apoptosis in response to DNA damage [XREF_BIBR, XREF_BIBR, XREF_BIBR]."

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IndraLab

Statements

TP53 bound to PIN1 activates TP53. 2 / 2

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