IndraLab

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IL1B increases the amount of SDC4. 10 / 10
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"In recent years, we and others have reported that cytokines tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β) induce Sdc4 expression to mediate different musculoskeletal pathologies including rheumatoid arthritis, osteoarthritis (OA), and IVD degeneration [79-81]."
38569642
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"In recent years, we and others have reported that cytokines tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β) induce Sdc4 expression to mediate different musculoskeletal pathologies including rheumatoid arthritis, osteoarthritis (OA), and IVD degeneration [79-81]."
38569642
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"CTGF has been shown to suppress IL-1β - induced mRNA levels of MMP-3, ADAMTS5, syndecan-4 and prolyl hydroxylase 3 by binding to cell surface integrin receptors α β and α β in healthy NP cells33."
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"Importantly, analysis of human NP tissues showed a strong correlation between levels of SDC4 and ADAMTS-5 with aggrecan neoepitopes, suggesting that an increase in SDC4 expression by cytokines IL-1beta and TNF-alpha contributes to aggrecan turnover in human disease."
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"Wang et al. have demonstrated that IL-1β treatment increases syndecan-4 (SDC4) expression and its promoter activity by activating NF-κB, leading to enhanced ADAMTS-5 synthesis and aggrecan degradation[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Through the further reading of the literature, we found that TNF-α and IL-1β can upregulate the expression of SDC4 in cartilage tissue through the NF-κB pathway, activate ADAMTS-4, -5, and upregulate MMPs, thereby causing the degradation of ECM and leading to cartilage degeneration ."
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"Moreover, SDC4 mRNA expression in beta-cells is transiently upregulated by IL-1beta via the Src-STAT3 pathway [XREF_BIBR]."
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"We capitalized on our previous finding that mediators of innate immunity, i.e., TNFα and IL-1β, upregulate production and shedding of syndecan-4 from cardiac myocytes and fibroblasts [18,20], in order to investigate whether immunomodulatory therapy affected syndecan-4 levels in such cells."
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"Taken together, these results suggest that in islets IL-1β induces SDC4 expression and its subsequent intracytoplasmic transportation to the cell and also MMP9 expression and release."
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"Wang et al. demonstrated that TNF-α and IL-1β upregulated the expression of SDC4 in NP cells."
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