IndraLab

Statements

IL1B increases the amount of SDC4. 4 / 4
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"CTGF has been shown to suppress IL-1β - induced mRNA levels of MMP-3, ADAMTS5, syndecan-4 and prolyl hydroxylase 3 by binding to cell surface integrin receptors α β and α β in healthy NP cells33."
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"Importantly, analysis of human NP tissues showed a strong correlation between levels of SDC4 and ADAMTS-5 with aggrecan neoepitopes, suggesting that an increase in SDC4 expression by cytokines IL-1beta and TNF-alpha contributes to aggrecan turnover in human disease."
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"Moreover, SDC4 mRNA expression in beta-cells is transiently upregulated by IL-1beta via the Src-STAT3 pathway [XREF_BIBR]."
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"Wang et al. have demonstrated that IL-1β treatment increases syndecan-4 (SDC4) expression and its promoter activity by activating NF-κB, leading to enhanced ADAMTS-5 synthesis and aggrecan degradation[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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