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USP10 decreases the amount of NPPA. 1 / 1

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"Compared with AdGFP transfection, AdUSP10 notably alleviated Ang II induced cardiomyocyte enlargement, accompanied by significant decreases in the expression of the fetal genes Anp, Bnp, and Myh7; in contrast, USP10 silencing significantly exacerbated myocyte hypertrophy and upregulated the expression of Anp, Bnp, and Myh7 compared with that in primary cells infected with AdshRNA, suggesting that USP10 can directly mitigate the hypertrophic growth of isolated myocytes induced by Ang II."

33170082

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IndraLab

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USP10 decreases the amount of NPPA. 1 / 1

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