IndraLab

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USP19 deubiquitinates FOXO1. 4 / 4
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"In microglia, FOXO1 positively regulated IL-10 expression at the transcriptional level, and USP19 was implicated in the deubiquitination of FOXO1."
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"USP19 mediated the deubiquitination of FOXO1 to activate IL-10/IL-10R1 signaling, thereby regulating microglial M1/M2 polarization."
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"Bioinformatic analysis based on Ubibrowser 2.0 predicted that USP19 might mediate the deubiquitination of FOXO1."
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"Low-dose lipopolysaccharide (LPS) activates the IL-10/IL-10R1 signaling pathway through the deubiquitination of FOXO1 mediated by USP19, regulates microglial polarization, reduces brain edema, blood-brain barrier disruption, neuroinflammation, etc., and has a protective effect on EBI [88]."
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