IndraLab

Statements

COPS6 inhibits MYC. 3 / 3
| 3
reach
"While CSN6 expression increased Myc transcriptional activity, CSN6 knockdown by shRNA reduced Myc transcriptional activity (XREF_FIG)."
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reach
"Knockdown of CSN6 decreased the steady-state expression of Myc protein in HCT116 Fbxw7 +/+ but not in HCT116 Fbxw7 -/- cells (XREF_FIG)."
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"Compared with empty vector transfected control cells, cells transfected with CSN6 had a decelerated endogenous Myc turnover rate (XREF_FIG); the pulse chase analyses of over expressed Myc with CSN6 or with shRNA mediated CSN6 knockdown indicated that over expression of CSN6 stabilized Myc while shRNA-CSN6 increased Myc degradation (XREF_FIG)."
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