IndraLab

Statements

USP47 activates Neoplasms. 6 / 6
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"Ubiquitin-specific peptidase 47 expression is elevated in many tumors and is involved in multiple expression regulating mechanisms, including transcriptional, post-transcriptional, and post-translational modifications."
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"Previous reports indicated that USP47 promotes colorectal cancer EMT and malignancy by stabilizing Snail and activating the Wnt signaling pathway [ 64 ] ."
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"Furthermore, xenograft assays demonstrated that silencing USP47 can inhibit LUSC tumor growth in vivo."
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"Functional experimental results showed that USP47 promoted the cell proliferation in vitro and tumor growth in vivo ."
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"Overexpression of USP47 could reduce the tumor inhibition induced by LINC00668 knockout (Hu et al., 2019)."
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"Thus , the findings here indicate that USP47 can promote tumor proliferation by regulating levels of p53 ."
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