IndraLab

Statements

USP47 activates Neoplasms. 12 / 12
| 2 10
reach
"Functional experimental results showed that USP47 promoted the cell proliferation in vitro and tumor growth in vivo ."
35141006
reach
"Ubiquitin-specific peptidase 47 expression is elevated in many tumors and is involved in multiple expression regulating mechanisms, including transcriptional, post-transcriptional, and post-translational modifications."
34604226
reach
"Furthermore, we identify Snai1 as a deubiquitination target of USP47, explaining USP47-dependent activation of the epithelial-mesenchymal transition pathway and tumor progression."
39998882
reach
"Furthermore, xenograft assays demonstrated that silencing USP47 can inhibit LUSC tumor growth in vivo."
35254655
reach
"Consistent with in vitro results, USP47 knockdown drastically inhibited tumor growth in vivo (Figure 2F and Supplemental Figure 6F)."
39998882
reach
"Conversely, USP47 overexpression markedly accelerated tumor growth, yielding larger tumors and higher weights (Supplemental Figure 7, I and J)."
39998882
eidos
"Thus , the findings here indicate that USP47 can promote tumor proliferation by regulating levels of p53 ."
32370049
reach
"Overexpression of USP47 could reduce the tumor inhibition induced by LINC00668 knockout (Hu et al., 2019)."
34604226
reach
"USP47 subsequently stabilizes Snail by deubiquitination and promotes EMT and tumor metastasis (35)."
35616129
eidos
"Previous reports indicated that USP47 promotes colorectal cancer EMT and malignancy by stabilizing Snail and activating the Wnt signaling pathway [ 64 ] ."
31133011
reach
"Knockdown of USP47 induces CDC25A accumulation and the inhibition of tumor growth."
37686524
reach
"Yu et al also reported that USP47 and SMURF2 can mediate CC cell proliferation and tumor progression by reversibly manipulating SATB1 ubiquitination."
37158531