IndraLab

Statements

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"Inhibition of the Otub1 and c-Maf axis by the herbal acevaltrate induces myeloma cell apoptosis."
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"OTUB1 knockdown induces apoptosis in melanoma cells and inhibits cell-cycle progression."
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"OTUB1-depleted WM-266-4 cells accumulated in the G1 phase; this finding strongly supports the evidence that OTUB1 depletion in melanoma cells triggers apoptosis (Fig. 2D)."
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"To further support our hypothesis of apoptosis by OTUB1 knockdown, we subjected WM-266-4 cells to Z-VAD treatment with siRNA for OTUB1."
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"Next, we used the PathScan Stress and Apoptosis Signaling Antibody Array to find out the relationship between OTUB1 knockdown-activated cell signaling pathways and apoptosis."
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"In this study, we showed that OTUB1 knockdown in melanoma cells induces apoptotic cell death by upregulating TRAIL (Fig. 4F)."
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"The PI/Annexin V double staining coupled with FACS analysis showed that overexpression of OTUB1 decreased cell apoptosis, which could be partially rescued by further YAP knockdown in MKN28 cells (Supplementary Fig. 2I, J)."
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"Furthermore, OTUB1 overexpression reversed the apoptosis induced by the inhibition of BRAF, pointing towards a potential mechanism of cancer recurrence and suggesting that the expression of OTUB1 is essential for melanoma-cell survival."
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"Combined in vivo and in vitro experiments comprising mice lacking OTUB1 specifically in liver parenchymal cells (OTUB1 LPC-KO) and human OTUB1 deficient HepG2 cells revealed that OTUB1 prevented hepatocyte necroptosis but not apoptosis upon infection with Lm and DGal and TNF challenge."
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"Furthermore, apoptosis was similarly promoted under suspension culture by OTUB1 knockdown to TAZ knockdown, suggesting that OTUB1 has a critical role in sustaining TAZ levels, resulting in anoikis res[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The PI/Annexin V double staining coupled with FACS analysis showed that the knockdown of OTUB1 increased cell apoptosis, which could be partially rescued by further YAP over-expression in MKN28 cells (Fig. 4K, L)."
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"Silencing OTUB1 promotes apoptosis and cell cycle arrest at G1 phase, inhibiting cell proliferation."
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"The PI/Annexin V double staining coupled with FACS analysis showed that knockdown of OTUB1 increased cell apoptosis, which could be rescued by further YAP-S5A over-expression in MKN28 cells (Supplementary Fig. 3K, L)."
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"Overexpression of OTUB1 promoted GBM cell metastasis, proliferation, G1 to S phase transition, and suppressed apoptosis in vitro."
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"Flow cytometry analysis revealed that OTUB1 overexpression facilitated the transition of the cell cycle from G1 to S phase and concurrently inhibited apoptosis (Figures 3C and D; Figures S3C and D)."
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"OTUB1 attenuates neuronal apoptosis after intracerebral hemorrhage."
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"The present study demonstrated that OTUB1 induced G1 to S phase transition, suppressed apoptosis, and promoted cell proliferation and invasion in vitro."
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"Next, we observed that knockdown of OTUB1 inhibits AML cell proliferation and promotes AML cell apoptosis and G0/G1 phase blockade using CCK-8 assay, western blotting, and flow cytometry."
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