IndraLab

Statements

reach
"EGCG was shown to inhibit the activity of IKKbeta which is the key kinase in the canonical pathway for NF-kappaB activation in MyD88 dependent pathway of TLRs."
16890209
reach
"We observed that EGCG decreased the triglyceride (TG) concentration in rat livers and suppressed TLR4, TRAF6, IKKbeta, p-IKKbeta, p-NF-kappaB, and TNF-alpha levels compared with those in the HFD group, whereas PI3K, AKT, IRS-1, and IRS-2 indicators were improved."
32281563
reach
"We have also shown that EGCG inhibits IKK-alpha and IKK-beta activity in SAOS-2 cells with concominant down regulation of NF-kappaB and induction of apoptosis."
20462508
reach
"The group found that flavonoid EGCG (Epigallocatechin-3-gallate) inhibits IKKbeta, a downstream signaling component of the MyD88 dependent pathway, in addition to inhibiting NF-kappaB activation induced by TLR4 and TLR2 agonists [XREF_BIBR]."
26899347