IndraLab

Statements

Modified UCHL1 increases the amount of APP. 3 / 3
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"Furthermore, viral expression of UCHL1 significantly lowered the APP level (p < 0.05) (XREF_FIG), and partial loss of UCHL1 markedly increased the APP level in APP23 and gad mice (p < 0.05) (XREF_FIG)."
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"UCHL1 inhibition led to marked accumulation of mature APP (p < 0.01) (XREF_FIG), whereas overexpression of UCHL1 significantly reduced mature APP level in 20E2 cells (p < 0.05) (XREF_FIG)."
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"Consistently, overexpression of UCHL1 increased the level of ubiquitinated wildtype APP as well (XREF_FIG)."
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