IndraLab

Statements

USP19 activates HTT. 5 / 5
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"The major finding of this work is that cytoplasmic USP19 can promote aggregation of the polyQ expanded Atx3 and Htt proteins by up-regulating their protein levels."
26808260
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"Based on these lines of evidence, we propose a model for triage decision of the Htt protein modulated by USP19 through HSP90."
29093475
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"A mechanism of auto-inhibition of USP19 and activation by HSP90 is proposed, on which USP19 modulates the protein level of polyQ expanded huntingtin in cells."
33094816
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"Cytoplasmic Ubiquitin Specific Protease 19 (USP19) Modulates Aggregation of Polyglutamine Expanded Ataxin-3 and Huntingtin through the HSP90 Chaperone."
26808260
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"Our previous study has demonstrated that cytoplasmic ubiquitin specific protease 19 (USP19), through interacting with HSP90, up-regulates the protein levels of the N-terminal 552-residue fragments of Htt (Htt-N552) with normal and expanded polyQ, and consequently increases the aggregates formed by polyQ expanded Htt-N552 31."
29093475