IndraLab

Statements

TNFAIP8L3 increases the amount of USP19. 6 / 6
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"In vivo experiments in mice suggested that TIPE3 inhibited apoptosis of tumor cells and promoted macrophage M2-type polarization in tumor tissues by up-regulating the protein expression of USP19."
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"Furthermore, TIPE3 upregulated USP19 protein expression, which accelerated autophagy."
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"TIPE3 upregulates the expression of USP19, enhancing autophagy."
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"Western blotting results showed that TIPE3 overexpression could upregulate the expression of USP19 following L-OHP treatment in both LoVo and SW480 cell lines (Fig. 4A)."
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"In summary, TIPE3 promotes cellular autophagy by elevating the expression of USP19/Beclin1, thereby increasing drug resistance to L-OHP in CRC cells."
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"In addition, consistent with the results of the experiments in LoVo and SW480 cells, TIPE3 also increased the protein expression level of USP19 in mouse tumor tissues (Fig. 7L, O)."
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