IndraLab

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Methylene blue inhibits NLRP3. 21 / 21
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"HIGHLIGHTS - Cytogenetic abnormalities and innate immune activation are seen in myelodysplasia - The NLRP3 inflammasome is a core element generating marrow failure of myelodysplasia - In April 2018 methylene blue was reported to potently inhibit NLRP3 inflammasome function - Methylene blue has benign side effects and has been in human use for a century - Study of methylene blue treatment of myelodysplasia would be a low-risk intervention Introduction -- myelodysplasia."
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"Of central importance to MDS, three recent independent studies showed that MB inhibits NLRP3 inflammasome function."
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"Ahn et al. showed that MB inhibited LPS stimulated increase in murine NLRP3 function."
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"Lin et al. showed that MB inhibited murine cord transection initiated NLRP3 activation."
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"We have only indirect evidence MB indeed inhibits NLRP3 activity in vivo."
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"We showed that methylene blue can alleviate the apoptosis and inflammatory response induced by renal IR injury in mice, and its relevant mechanism may be related to the fact that methylene blue can negatively regulate NLRP3 signaling pathway."
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"In the present study, we demonstrated that MB treatment blocked the priming step of inflammasome activation as well as up-regulation of pro-IL-1beta and NLRP3 proteins XREF_BIBR, XREF_BIBR."
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"In the same study it was demonstrated that MB downregulates ROS , NFB , and NLRP3 by the antioxidant effect which reduces NFkB and NLRP3 proteins expression by ROS / NF-KB-NLRP3 pathway ."
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"Specifically, MB blocks the NLRP3, NLRC4, and AIM2 inflammasomes as well as non canonical inflammasome."
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"In the same study it was demonstrated that MB downregulates ROS, NFB, and NLRP 3 by the antioxidant effect which reduces NFkB and NLRP 3 proteins expression by ROS and NF-KB-NLRP 3 pathway."
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"Methylene blue, a broad-spectrum inflammasome inhibitor, blocks NLRC4, NLRP3, AIM2, and non-canonical inflammasomes, which improves the survival rate of mice challenged with LPS [261]."
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"They also observed that methylene blue markedly reduced the appearance of NLRP3 and NLRC4 inflammasomes in stimulated microglia."
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"The MB inhibits the formation of NLRP3 complex XREF_BIBR."
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"Methylene blue inhibits NLRP3, NLRC4, AIM2, and non canonical inflammasome activation."
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"Methylene blue inhibits NLRP3 inflammasome activation."
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"Similarly, STZ-induced diabetic rats also had elevated retinal NLRP3 protein, which was attenuated by sulforaphane [121] and methylene blue [122] treatment."
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"Methylene Blue weakens the NF-κβ signaling by reducing the secretion of caspase-1, IL-1β, as well as ASC aggregation, and NLRP3 promoter activity, and subsequently prevents the formation of NLRP3 complex, the cytokine storm, and its consequences (27) (Figure 1 E)."
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"These data suggest that MB inhibited assembly of the NLRP3 inflammasome, which is upstream of caspase-1, IL-1beta, and IL-18 maturation."
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"This result suggests that MB inhibits NLRP3 inflammasome activation as well as the priming step."
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"Methylene blue inhibits NLRP3, NLRC4, AIM2, and non canonical inflammasome activation."
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"Methylene blue attenuates mitochondrial ROS production, phagocytosis, caspase 1 activity, and NLRP3 promoter activity."
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