IndraLab

Statements

USP32 binds BAG3. 4 / 4
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"To further elucidate the mechanism of action of USP32 in NSCLC, we screened H1299 cells for interacting proteins and found that USP32 interacts with BAG3 (Bcl2-associated athanogene 3) and deubiquitinates and stabilizes BAG3 in a deubiquitinating activity-dependent manner."
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"This suggests a possible interaction between BAG3 (yellow protein) and USP32 (blue protein)."
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"Given that USP32 is a DUB, we first performed an organizing and query analysis of the TCGA database to investigate the association between USP32 and BAG3."
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"However, the role of deubiquitinating enzymes in the regulation of BAG3 is unclear.In this study, we know from immunofluorescence co-localization experiments that USP32 co-localizes with BAG3 in the cytoplasm, and that USP32 can directly bind to BAG3 by exogenous and exogenous immunoprecipitation."
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