IndraLab

Statements

RAB11A activates KCNH2. 3 / 3
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"This is pertinent as robust Rab11 mediated recycling of hERG channels has been observed."
29725305
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"These results show that SGK enhances the expression level of mature hERG channels by inhibiting Nedd4-2 as well as by promoting Rab11 mediated hERG recycling."
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"We found that SGK1 activator had no protectiveness on the prolonged QTc intervals and sudden death in pCH guinea pigs although previous studies have demonstrated that SGK1 activation increases hERG protein expression in HEK cell by inhibiting Nedd4-2 activity as well as promoting Rab11-mediated hERG recycling (Maier et al., 2006; Lamothe and Zhang, 2013)."
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