IndraLab

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USP1 activates FANCD2. 10 / 11
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"Because USP1 is reported to target PCNA and FANCD2 during DNA repair (Nijman et al., 2005; Huang et al., 2006), we also checked if USP1 knockdown produced DNA damage."
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"The above bioinformatics analysis showed that the expression of USP1 could promote the expression of homologous recombination repair related genes (FANCD2 and BRCA1), which negatively correlates with clinical outcome in patients with hepatocellular carcinoma."
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"USP1 knockdown has been observed to downregulate the DNA repair-related substrates FANCD2 and ID1; thus, it can be considered a target for regulating DNA repair[24]."
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"Upon DNA damage, USP1 self-inactivates through autocleavage, which enables its own degradation and, in turn, upregulates ub-PCNA and ub-FANCD2 on chromatin, facilitating DNA lesion bypass by TLS and DNA repair by the FA pathway, respectively (4, 6)."
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"USP1 targets FANCD2, FANC1, and PCNA for deubiquitylation."
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"This observation indicates that UAF1 activates the DUB enzyme activity of USP1 and that it functions as a scaffolding protein for USP1 targeting FANCD2 [XREF_BIBR, XREF_BIBR]."
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"The uncoupling of monoubiquitination and chromatin enrichment from nuclear foci formation and effective ICL repair has previously been observed : Usp1 -/- murine embryonic fibroblasts display elevated levels of monoubiquitinated Fancd2 and Fancd2 chromatin localization, but fail to support Fancd2 nuclear foci formation and exhibit ICL-hypersensitivity XREF_BIBR."
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"In USP1 depleted cells this fraction is also enriched in SQSTM1 (sequestosome 1), the aggresome marker HDAC6 (histone deacetylase 6), and the prototype of USP1 targets FANCD2 (FA complementation group D2)."
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"In addition, DUBs involved in DNA damage signaling are USP1 that targets PCNA (proliferating cell nuclear antigen) [76], FANCD2 and FANCI (the Fanconi anemia proteins) [93,94], and USP3 and USP16 that[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP1 depletion, which also causes an increase in FANCD2-Ub, even in the absence of DNA damage, increased promoter binding of FANCD2-Ub (XREF_FIG)."
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