IndraLab

Statements

CRBN inhibits KCNMA1. 4 / 4
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"Consistent with this idea, it has been observed that cereblon, a protein related to intellectual disability, downregulates BK channel activity at hippocampal CA3 terminals affecting paired-pulse ratio and short-term plasticity, but not long-term plasticity [200]."
36834817
reach
"CRL4A (CRBN) E3 ubiquitin ligase restricts BK channel activity and prevents epileptogenesis."
24845235
reach
"Based on the study designed to overexpress CRBN and BK channel in heterologous cells, wild-type (WT) CRBN can restrict excessive BK channel in ER for a balance of BK activity in cell membrane to prevent induced epileptogenesis [XREF_BIBR]."
29370161
reach
"CRL4A (CRBN) E3 ubiquitin ligase restricts BK channel activity and prevents epileptogenesis."
25840593