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USP8 deubiquitinates KCNN4. 3 / 4
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"Further, overexpression of wild-type USP8 accelerates channel deubiquitylation, while either a catalytically inactive mutant USP8 or siRNA mediated knockdown of USP8 enhanced accumulation of ubiquitylated KCa3.1, thereby inhibiting channel degradation."
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"Further, we demonstrated that KCa3.1 is initially ubiquitylated following endocytosis and then deubiquitylated by USP8 prior to lysosomal degradation XREF_BIBR."
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"On the other hand, unassembled and/or misfolded KCa3.1 channel is rapidly targeted for lysosomal degradation via the ESCRT-and Rab7-dependent pathway, and USP8 regulates the rate of KCa3.1 channel deg[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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