IndraLab

Statements

USP8 deubiquitinates KCNN4. 3 / 3
1 | 2
reach
"Further, we demonstrated that KCa3.1 is initially ubiquitylated following endocytosis and then deubiquitylated by USP8 prior to lysosomal degradation XREF_BIBR."
24632741
ubibrowser
"Review"
27775833
reach
"Further, overexpression of wild-type USP8 accelerates channel deubiquitylation, while either a catalytically inactive mutant USP8 or siRNA mediated knockdown of USP8 enhanced accumulation of ubiquitylated KCa3.1, thereby inhibiting channel degradation."
21828287