IndraLab

Statements

Emodin inhibits JUN. 5 / 5
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"Furthermore, activation of JNK counteracted the inhibitory effects of emodin on c-Jun, indicating that emodin repressed the activation of c-Jun via JNK signaling in inflammatory responses."
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"We further demonstrated that emodin reduced the transcriptional activity of activator protein-1 (AP-1) and nuclear factor kappaB (NF-kappaB), two important nuclear transcription factors involved in MMP-9 expression."
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"Some findings dictate emodin suppresses the activator protein Activator Protein-1 (AP-1) and NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B cells) signaling [XREF_BIBR, XREF_BIBR] pathways, respectively, thus inhibiting the expression of matrix metallopeptidase 9 (MMP-9) [XREF_BIBR] as shown in XREF_FIG and hence limiting the invasiveness in various cancer cells."
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"Moreover, emodin inhibits the activity of c-Jun through the upregulation of Nur77 (Figure 6B)."
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"Curcumin and emodin block the CSN directed c-Jun signaling pathway, which results in diminished c-Jun steady state levels in HeLa cells."
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