IndraLab

Statements

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"Downregulation of USP22 inhibited OS cell proliferation, invasion, and EMT in vitro."
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"The overexpression or knockdown of USP22 promoted the proliferation of NPC."
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"As shown in Figure XREF_FIG to XREF_FIG, silencing USP22 significantly inhibited proliferation and generated a smaller number of colonies in Bel/Fu cells."
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"In this study, we found that silencing of USP22 inhibited proliferation of gastric cancer cells and suppressed the cancer stem cell spheroid formation in serum-free culture."
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"In summary, USP22 downregulation reduces cancer cell proliferation, migration, and invasion and reduces tumor growth and metastasis in vivo."
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"In further functional analysis, ADAM9 deletion abolished USP22-triggered suppression in proliferation ( Fig. 5 B–D), promotion in apoptosis ( Fig. 5 E), and weakness in invasion and migration abilitie[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP22 silencing inhibits GC cells proliferation."
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"Depletion of USP22 suppressed cell proliferation in vitro and tumor growth in vivo."
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"Together, these data showed that USP22 silencing inhibited the proliferation of ATC cells in vitro ."
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"Consistently, we demonstrated that USP22 silencing inhibited the proliferation of human ATC cells (8505C and CAL-62)."
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"USP22 silencing by shRNA inhibits proliferation, induces apoptosis and arrests cells at the G0/G1 phases in NSCLC cells and curbs human NSCLC tumor growth in a mouse xenograft model."
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"USP22 Silencing Inhibits Proliferation and Induces Apoptosis and Cell Cycle Arrest in NSCLC Cells."
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"Downregulation of USP22 reduces in vitro cancer cell proliferation, survival, migration, and invasion, and decreases in vivo tumor growth and metastasis [6, 10–13]."
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"We found that downregulation of USP22 could inhibit Sao-2 cell proliferation, migration, invasion, and induce apoptosis."
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"Downregulation of USP22 inhibits Sao-2 proliferation."
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"Our in vitro and in vivo studies showed that USP22 silencing by shRNA inhibits proliferation and induces cell cycle arrest and apoptosis in human NSCLC cells in vitro and curbs human NSCLC tumor growth in a mouse xenograft model in vivo ."
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"Additionally, investigation into the underlying mechanism, using small interfering RNA, revealed that the downregulation of USP22 inhibited proliferation and promoted apoptosis though the phosphoinositide 3-kinase/protein kinase B signaling pathway."
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"It was found that silencing USP22 in A375 cells significantly suppressed cell proliferation (XREF_FIG; P < 0.01)."
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"The results of MTT, colony formation, EdU‐incorporation and flow cytometry assays demonstrated that overexpression of CDK11B significantly reversed the reduction in cell proliferation induced by USP22 knockout (Figure 4G‒J)."
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"Moreover, USP22 downregulation repressed cell proliferation, invasion and epithelial-mesenchymal transition (EMT) via inactivation of PI3K/Akt signaling pathway in osteosarcoma cells (28)."
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"In this study, we used siRNA to specifically suppress expression of USP22, and we observed that the knock-down of USP22 could effectively inhibit HeLa cell proliferation and induce cell cycle arrest."
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"USP22 also inhibits tumor proliferation via contributing to the deubiquitination of PTEN (Ren et al., 2022)."
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"Downregulation of USP22 inhibited OS cell proliferation, invasion, and epithelial-mesenchymal transition (EMT) in vitro."
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"USP22 downregulation inhibited OS cell proliferation, invasion, and epithelial-mesenchymal transition (EMT) in vitro."
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"Downregulation of USP22 Inhibited OS Cell Proliferation and Invasion In Vitro."
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"The assay results showed that USP22 downregulation significantly inhibited the proliferation (XREF_FIG) and invasion (XREF_FIG) of U2OS and MG-63 cells."
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"We also suggested that downregulation of USP22 inhibited OS cell proliferation and invasion in vitro."
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"Knockdown of USP22 can activate STAT1 signaling pathway, inhibit T-cell depletion, and promote the proliferation and activation of NK cells (75)."
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"XREF_BIBR - XREF_BIBR Depletion of USP22 led to the accumulation in G1 phase and blocked the proliferation of CRC cells."
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"Knock-down of USP22 by small interfering RNA interference inhibits HepG2 cell proliferation and induces cell cycle arrest."
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"Similarly, Zhao et al. reported that USP22 depletion suppressed cell survival and proliferation as well as tumor growth and lung metastasis of anaplastic thyroid carcinoma cells XREF_BIBR."
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"XREF_BIBR In addition, another study demonstrated that silencing USP22 could inhibit proliferation and induce cell cycle arrest in bladder cancer cells."
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"A recent study suggested that USP22 could increase TGF-β expression and promote the epithelial–mesenchymal transition (EMT). xref In addition, another study demonstrated that silencing USP22 could inhibit proliferation and induce cell cycle arrest in bladder cancer cells. xref Furthermore, USP22 was also reported with high expression level in different malignancies, such as breast cancer xref and colorectal cancer. xref Thus, these lines of evidence strongly suggested that the oncogenic role of the USP22 might contribute to progression and predict the prognosis and become an attractive therapeutic target in cancers."
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"Furthermore, ALKBH5-mediated m6A deficiency increases the expression of USP22 and RNF40 in osteosarcomas, promoting osteosarcoma cell growth and proliferation [40]."
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"Additionally, investigation into the underlying mechanism, using small interfering RNA, revealed that the downregulation of USP22 inhibited proliferation and promoted apoptosis though the phosphoinositide 3-kinase/protein kinase B signaling pathway."
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"USP22 depletion could significantly inhibit the proliferation and invasion, and promote the apoptosis of ATC cells in vitro."
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"USP22 depletion inhibits the proliferation of ATC cells in vitro."
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"Knockdown of USP22 was found to suppress cell proliferation in vitro and tumour growth in vivo by inducing G1 phase cell cycle arrest through synergy with TGF-beta1 (Ji et al., 2015)."
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