IndraLab

Statements

USP15 inhibits PRKN. 11 / 12
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"Therefore, the activities of USP30 and USP15 in antagonizing Parkin would be expected to promote PD phenotypes [62]."
38931449
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"In contrast, a recent report demonstrated that in Drosophila the age dependent increase in mitophagy in both muscle and dopaminergic neurons is dependent on PINK1 and Parkin, and the knockdown of USP15 and USP30 rescues mitophagy in Parkin deficient organisms."
31972372
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"For example, USP15, USP30, and USP35 are known to eliminate the ubiquitin- and parkin-mediated signals, consequently delaying or disrupting mitophagy (5)."
34674795
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"In PD cases with diminished but non-zero Parkin activity, USP15 inhibition could enable residual Parkin to exert its neuroprotective function more effectively."
24852371
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"The OMM localized DUB ubiquitin specific processing proteases USP30 and USP15 antagonize PARKIN activity by cleaving ubiquitin chains on mitochondria."
28512624
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"We wondered whether USP15 knockdown would promote Parkin function in PARK2 mutant PD patient cells with reduced but non-zero Parkin activity."
24852371
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"In this regard, USP15 and USP30 were found to antagonize Parkin activity by competing for the common substrates on OMM."
32850842
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"USP8, USP14, USP15, USP30, USP33, and USP35 have been shown to antagonize Parkin activity [[92], [93], [94], [95], [96], [97]]."
38295575
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"It was recently shown that knockdown of USP15 enhanced Parkin dependent mitophagy and global upregulation of mitochondrial ubiquitylation upon CCCP [XREF_BIBR]."
25345844
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"Notably, among them there are proteins, which are able to antagonise Parkin activity, such as the anti-apoptotic members of the Bcl-2 family Bcl-X L and Mcl-1, or the deubiquitinases USP30 ( Bingol et[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28797885
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"More in detail, USP15 was shown to inhibit CCCP induced mitophagy in Parkin transfected Hela cells depending on its DUB activity and RNAi mediated silencing of USP15 enhanced Parkin mediated mitophagy[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26550693