IndraLab

Statements

USP15 inhibits PRKN. 8 / 9
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"Interestingly, USP15 strongly inhibited Parkin-mediated Human Molecular Genetics, 2014, Vol."
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"In PD cases with diminished but non-zero Parkin activity, USP15 inhibition could enable residual Parkin to exert its neuroprotective function more effectively."
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"In this regard, USP15 and USP30 were found to antagonize Parkin activity by competing for the common substrates on OMM."
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"The OMM localized DUB ubiquitin specific processing proteases USP30 and USP15 antagonize PARKIN activity by cleaving ubiquitin chains on mitochondria."
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"More in detail, USP15 was shown to inhibit CCCP induced mitophagy in Parkin transfected Hela cells depending on its DUB activity and RNAi mediated silencing of USP15 enhanced Parkin mediated mitophagy[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"It was recently shown that knockdown of USP15 enhanced Parkin dependent mitophagy and global upregulation of mitochondrial ubiquitylation upon CCCP [XREF_BIBR]."
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"We wondered whether USP15 knockdown would promote Parkin function in PARK2 mutant PD patient cells with reduced but non-zero Parkin activity."
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"In contrast, a recent report demonstrated that in Drosophila the age dependent increase in mitophagy in both muscle and dopaminergic neurons is dependent on PINK1 and Parkin, and the knockdown of USP15 and USP30 rescues mitophagy in Parkin deficient organisms."
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