IndraLab

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Colchicine inhibits CASP1. 14 / 14
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"Thus, exploring the potential inhibition of caspase-1 by colchicine provides useful information to ameliorate the health condition of COVID-19 patients."
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"In patients with ACS , colchicine acutely suppressed the caspase-1 activity and the local production of proinflammatory interleukins ( IL-6 , IL-1beta , and IL-18 ) and chemokines , which are key mediators in the inflammatory pathway of the coronary atherothrombosis ( 27-29 ) ."
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"Colchicine inhibits the activation of NALRP3 and CASPASE-1."
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"Whether colchicine inhibits caspase-1 at physiologic concentrations , or whether colchicine accumulation in leukocytes is sufficient to block the inflammasome , remains to be determined ."
| PMC
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"In patients with ACS, colchicine acutely suppressed the caspase-1 activity and the local production of proinflammatory interleukins (IL-6, IL-1β, and IL-18) and chemokines, which are key mediators in the inflammatory pathway of the coronary atherothrombosis (27–29)."
34169101
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"By immunofluorescence staining and other methods, Takuma Misawa et al. have successfully demonstrated that the assembly of not only NLRP3 and ASC but also NLRP3 inflammasomes into NLRP3 inflammasome complexes requires the transport function of microtubules.17 Because colchicine can inhibit the synthesis of microtubules and promote the degradation of microtubules, it can effectively inhibit the assembly of NLRP3 inflammasome complexes, and ultimately effectively inhibit the inflammatory response.3.2.3 Colchicine can effectively inhibit Caspase-1."
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"4 Colchicine has been used to suppress caspase-1 activation by inhibiting inflammasome signaling , 5 and it has been the mainstay treatment in familial Mediterranean fever ( FMF ) , gout , and mucocutaneous Beh c et 's Syndrome ( BS ) ."
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"Moreover, colchicine downregulates NLRP3 inflammasome by antagonizing caspase-1 activity and potential triggering factors (e.g., P2X2 and P2X7 channels and Reactive Oxygen Species) (104)."
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"As depicted in Figure 3 , compared with untreated FMF-derived PBMCs , DMAPT and colchicine significantly reduced LPS / ATP-induced NLRP3 ( 0.39 + / -0.12 , P < 0.001 and 0.31 + / -0.12 , P < 0.001 ) , MEFV ( 0.384 + / -0.145 , P < 0.001 and 0.332 + / -0.089 , P < 0.001 ) , CASP1 ( 0.48 + / -0.13 , P =0 .0023 and 0.37 + / -0.13 , P =0 .002 ) , and IL-1beta ( 0.09 + / -0.09 , P < 0.0001 and 0.42 + / -0.09 , P =0 .002 ) mRNA expressions ."
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"Thus, exploring the potential inhibition of caspase-1 by colchicine provides useful information to ameliorate the health condition of COVID-19 patients.Dexamethasone is a cheap and globally available corticosteroid commonly used as an anti-inflammatory and immunosuppressant."
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"On the other hand, a standard low dose of colchicine (0.6 mg) drastically reduced serum levels of inflammasome products and caspase-1 monocyte production [22]."
35107804
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"In patients with ACS, colchicine acutely suppressed the caspase-1 activity and the local production of proinflammatory interleukins (IL-6, IL-1β, and IL-18) and chemokines, which are key mediators in the inflammatory pathway of the coronary atherothrombosis (27) (28) (29) ."
34169101
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"Colchicine also inhibits the NLRP3 inflammasome and caspase-1 and the associated inflammatory response and matrix metallopeptidase ( MMP ) expression ( including MMP2 and MMP9 ) ( 113 ) ."
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"Whether colchicine inhibits caspase-1 at physiologic concentrations, or whether colchicine accumulation in leukocytes is sufficient to block the inflammasome, remains to be determined.Another mechanism by which colchicine may suppress inflammation is by inhibition of superoxide production by neutrophils."
| PMC