IndraLab

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Colchicine inhibits CASP1. 22 / 22
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"Colchicine inhibits the activation of NALRP3 and CASPASE-1."
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"In patients with ACS, colchicine acutely suppressed the caspase-1 activity and the local production of proinflammatory interleukins (IL-6, IL-1β, and IL-18) and chemokines, which are key mediators in the inflammatory pathway of the coronary atherothrombosis (27–29)."
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"Moreover, colchicine downregulates NLRP3 inflammasome by antagonizing caspase-1 activity and potential triggering factors (e.g., P2X2 and P2X7 channels and Reactive Oxygen Species) (104)."
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"Thus, exploring the potential inhibition of caspase-1 by colchicine provides useful information to ameliorate the health condition of COVID-19 patients.Dexamethasone is a cheap and globally available corticosteroid commonly used as an anti-inflammatory and immunosuppressant."
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"On the other hand, a standard low dose of colchicine (0.6 mg) drastically reduced serum levels of inflammasome products and caspase-1 monocyte production [22]."
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"As depicted in Figure 3 , compared with untreated FMF-derived PBMCs , DMAPT and colchicine significantly reduced LPS / ATP-induced NLRP3 ( 0.39 + / -0.12 , P < 0.001 and 0.31 + / -0.12 , P < 0.001 ) , MEFV ( 0.384 + / -0.145 , P < 0.001 and 0.332 + / -0.089 , P < 0.001 ) , CASP1 ( 0.48 + / -0.13 , P =0 .0023 and 0.37 + / -0.13 , P =0 .002 ) , and IL-1beta ( 0.09 + / -0.09 , P < 0.0001 and 0.42 + / -0.09 , P =0 .002 ) mRNA expressions ."
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"Colchicine also inhibits the NLRP3 inflammasome and caspase-1 and the associated inflammatory response and matrix metallopeptidase ( MMP ) expression ( including MMP2 and MMP9 ) ( 113 ) ."
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"Overall, understanding inflammasome activation mechanisms and their implications for host defense and vascular inflammation is critical for advancing therapeutic interventions.Various drugs modulate the inflammasome, with colchicine limiting caspase-1 activation elicited by the inflammasome [113] and IFN-α exhibiting a dual inhibitory effect on the inflammasome [114]."
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"In patients with ACS , colchicine acutely suppressed the caspase-1 activity and the local production of proinflammatory interleukins ( IL-6 , IL-1beta , and IL-18 ) and chemokines , which are key mediators in the inflammatory pathway of the coronary atherothrombosis ( 27-29 ) ."
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"However, a low dose of colchicine inhibited the CASPASE-1 pathway in acute coronary syndrome patients [27], indicating that colchicine can regulate CASPASE-1 and that its dose is an key factor.The major metabolic process of colchicine is demethylation which is regulated by CYP3A4 in vivo [13,28], while the role of CYP1A1 in colchicine metabolism has not yet been reported."
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"In both CVB3 FB and HL-1 cells, colchicine down-regulated the NLRP3 inflammasome-related components ASC, caspase-1, and IL-1beta."
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"It has been reported that colchicine can inhibit the activation of caspase-1 by pyrin, a protein associated with the cytoskeleton ( Yu et al., 2007 )."
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"Colchicine has been demonstrated to inhibit the NLRP3 inflammasome and suppress caspase-1 activation in gout [25]."
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"By immunofluorescence staining and other methods, Takuma Misawa et al. have successfully demonstrated that the assembly of not only NLRP3 and ASC but also NLRP3 inflammasomes into NLRP3 inflammasome complexes requires the transport function of microtubules.17 Because colchicine can inhibit the synthesis of microtubules and promote the degradation of microtubules, it can effectively inhibit the assembly of NLRP3 inflammasome complexes, and ultimately effectively inhibit the inflammatory response.3.2.3 Colchicine can effectively inhibit Caspase-1."
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"In addition to the indirect action on chemotaxis, motility, and stimulation of leukocytes, colchicine has been demonstrated to inhibit the NLRP3 inflammasome, thereby suppressing caspase-1 activation in gout [108]."
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"Whether colchicine inhibits caspase-1 at physiologic concentrations , or whether colchicine accumulation in leukocytes is sufficient to block the inflammasome , remains to be determined ."
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"In addition to the indirect action on chemotaxis, motility, and stimulation of leukocytes, colchicine has been demonstrated to inhibit the NLRP3 inflammasome, thereby suppressing caspase-1 activation (32)."
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"Recent studies have shown that colchicine inhibits the NLRP3 inflammasome by reducing pore formation induced by P X (36), inhibiting caspase-1 activation (37), and suppressing microtubule synthesis (38)."
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"Colchicine has recently been shown to suppress the activation of caspase-1, the enzymatic component of the nucleotide-binding oligomerization domain (NOD) receptor family pyrin 3 (NLRP3)inflammasome."
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"Whether colchicine inhibits caspase-1 at physiologic concentrations, or whether colchicine accumulation in leukocytes is sufficient to block the inflammasome, remains to be determined.Another mechanism by which colchicine may suppress inflammation is by inhibition of superoxide production by neutrophils."
| PMC
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"Thus, exploring the potential inhibition of caspase-1 by colchicine provides useful information to ameliorate the health condition of COVID-19 patients."
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"Furthermore, in peripheral blood monocytes from ACS patients, colchicine inhibited caspase-1 activity and IL-1β production (52)."
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