IndraLab

Statements

Nifedipine inhibits KCNH2. 3 / 3
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"Nifedipine mediated reduction of both HERG and Kv1.5 channels could lead to the suppressions of both I Kr and I to currents in cardiomyocytes."
25893973
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"The I Ks was isolated by 100 nM E-4031 and 1 μM nifedipine in the external solution, eliminating the hERG and calcium currents."
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"In our experiments, verapamil caused high-affinity block of HERG current (IC50 = 143.0 nmol/L), a value close to those reported for verapamil block of L-type Ca2+ channels, whereas diltiazem weakly blocked HERG current (IC50 = 17.3 micromol/L), and nifedipine did not block HERG current."
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