IndraLab
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"Specifically, by inhibiting the activation of OTUB1 deubiquitination, ZnCM NPs could promote CCL5 degradation to induce tDCs and further inhibit the T-cell response, exhibiting Zn homeostasis regulation by ZnCM NPs in RA.In addition, it was shown that the expression of CCL5 was closely related to the activation of NF-κB signalling, leading to regulatory effects on cell fate [60]."
reach
"Collectively, the data above demonstrated that ZnCM NPs could inhibit the activation of OTUB1 deubiquitination, thereby promoting CCL5 degradation via NF-κB signalling to induce tDCs for further T-cell response inhibition, which explained the molecular mechanisms of Zn homeostasis regulation by ZnCM NPs to treat RA."