IndraLab

Statements

Metformin inhibits RELA. 14 / 14
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"The suppression of NFkappaB p65 (XREF_FIG) and IL-8 (XREF_FIG) by metformin was not altered by addition of compound C. On the other hand, compound C blocked a large portion of metformin caused decrement in ICAM-1 expression (XREF_FIG; 70%; p < 0.05 versus metformin plus TNFalpha group)."
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"The combination of EGCG and metformin has been shown to suppress NF-κb, p65, and STAT3 signaling pathways in melanoma cells."
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"As shown above, metformin inhibited NF-κB p65 independent of AMPK (Fig 4B)."
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"Metformin suppressed NOS2 ( iNOS ) and NF-kappaBp65 expression and nuclear translocation ( Figure 6D , F and not shown ) ."
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"Immunofluorescence staining and western blot analysis showed that metformin inhibited the nuclear localization of p65, a subunit of nuclear factor NF-kappaB."
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"Metformin combined with CO-1686 synergistically inhibited the p-IkappaB, p-IKKa and beta, p50 and p65."
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"As in LNCaP cells, metformin activated p-AMPK and reduced p65 and promoted cell death in MCF-7 cells."
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"Taken together, we proposed that metformin could inhibit NF-kappaB p65 signaling by activating AMPK and inhibiting downstream ERK / NF-kappaB to suppress lung cancer progression (XREF_FIG)."
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"However, pharmacological inhibition of AMPK did not abolish metformin’s suppression of NF-κB p65, sICAM-1, and TNFα in our study (Fig 4)."
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"Similarly, over-expression of N-cadherin in MCF-7 cells prevented metformin mediated inhibition of p65 and led to resistance to metformin mediated cell death in MCF-7 cells."
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"Taken together , we proposed that metformin could inhibit NF-kappaB p65 signaling by activating AMPK and inhibiting downstream ERK / NF-kappaB to suppress lung cancer progression ( Figure 5H ) ."
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"In addition, metformin nearly abrogated the binding of NF-kappaB subunit p65 to the iNOS promoter gene in lung tissue of obese mice."
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"Along with the upregulation of phosphorylated AMPKalpha and ACCalpha, metformin at 1.5 and 3mM inactivated NF-kappaB signalling components (p65 and IkappaBalpha) and the inflammatory genes (TNFA, IL6, IL1B and COX-2) which were activated by BHBA."
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"In our study, metformin exerted anti-inflammatory effects by concentration-dependently reducing the production of pro inflammatory cytokines via suppression of IkappaBalpha phosphorylation and translocation of NF-kappaB p65 from cytosol to the nucleus."
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