IndraLab

Statements

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"Activation of mTORC1 after feeding increases phosphorylation of ubiquitin-specific peptidase 20 (USP20) which stabilizes HMG-CoA reductase (HMGCR) and therefore promotes cholesterol synthesis."
38935546
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"This licenses USP20’s recruitment into the HMGCR complex and antagonizes its degradation, thereby stabilizing HMGCR and promoting cholesterol synthesis [133]."
36038892
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"USP20 stabilizes 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) to increase liver cholesterol biosynthesis, which aggravates metabolic disorders [14]."
39033101
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"In sum, these findings suggest that TBBPA enhances cholesterol synthesis by increasing USP20 protein levels, which in turn stabilizes the HMGCR protein."
39998957
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"USP20 was recruited to the HMGCR complex and antagonized its degradation, up-regulating cholesterol synthesis and converting absorbed glucose and other nutrients into cholesterol."
35754818