IndraLab

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VCPIP1 activates MIR7-3HG. 4 / 4
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"Although VCPIP1 overexpression led to significantly increased HBx in the Huh7 and HepG2 cells, it did not redice the amounts of HBx ubiquitination (Fig. 4C)."
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"As expected, ectopic VCPIP1 expression led to significantly increased HBx in a dose-dependent manner in both Huh7 and HepG2 cells (Fig. 2B)."
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"The dual-luciferase reporter assay showed that further VCPIP1 expression significantly enhanced the HBx-induced transactivation activity of NF-κB, AP-1, and SP-1 in the Huh7 and HepG2 cells, whereas VCPIP1 alone had no such effects (Fig. 7A)."
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"In addition, double knockdown of MATIIα and VCIP135 dramatically inhibits the growth in Huh7 and MHCC-97H cells (Fig. 5g and Supplementary Fig. S6c)."
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