IndraLab

Statements

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"As expected, downregulation of USP22 suppressed OS tumor growth and metastasis in vivo."
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"Collectively, these results suggested that USP22 depletion attenuates tumor growth and metastasis of ATC."
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"Moreover, USP22 overexpression can promote EMT and TGF-beta expression, whereas depletion of USP22 can reverse EMT and reduce metastasis of lung adenocarcinomas."
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"Meanwhile, downregulation of USP22 in anaplastic thyroid carcinoma cells may impede lung metastasis in vivo."
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"Similarly, Zhao et al. reported that USP22 depletion suppressed cell survival and proliferation as well as tumor growth and lung metastasis of anaplastic thyroid carcinoma cells XREF_BIBR."
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"USP22 inhibition abolished EPI-induced breast cancer metastasis."
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"In addition, downregulation of USP22 suppressed OS tumor growth and metastasis in vivo."
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"XREF_BIBR Downregulation of USP22 has been shown to suppress osteosarcoma growth and metastasis through PI3K and Akt pathway."
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"Moreover, USP22 ablation completely prevented lung metastasis, even in mice with tumors treated with EPI, because the lung luminol fluorescence activity and tumor nodules were both markedly decreased by USP22 deletion (Fig. 2, S to U)."
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"Consistent with in vitro findings, downregulation of USP22 in ATC cells impeded tumor growth and lung metastasis in vivo."
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"We also showed that ablation of tumor cell-intrinsic USP22 suppressed metastasis of pancreatic tumor cells in a T cell dependent manner."
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"Downregulation of USP22 Inhibited OS Tumor Growth and Metastasis In Vivo."
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"These results suggest that USP22 downregulation inhibited OS tumor growth and metastasis in vivo."
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