IndraLab

Statements

USP9X inhibits Ubiquitin. 4 / 4
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"Results from the in vitro experiments suggested that USP9X mediates the ubiquitin dependent degradation of AMPK-alpha2."
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"From this screening, we have now thoroughly validated that depletion of the ubiquitin-specific protease 9X (USP9X) in HeLa and oropharyngeal squamous cell carcinoma (UMSCC74A) cells using small interfering RNA (siRNA), leads to significantly decreased survival of cells after high-LET radiation."
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"USP9x has been reported to increase SMAD4 activity by removing an inhibitory ubiquitin moiety [XREF_BIBR]."
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"However, a few studies have suggested that USP9X has roles in hematological tumors.141 142 USP9X was found to inhibit cell death by inhibiting the ubiquitin degradation of myeloid cell leukemia-1 thus promoting disease progression."
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